The coronavirus epidemic continues despite the measures taken. At this stage, everyone’s greatest hope is the vaccines developed. While the World Health Organization states that more than 50 vaccines have been developed in the trials so far, the vaccines we hear the most among them are Pfizer-BionTech, Moderna, Sinovac and Oxford-AstraZeneca belonging to companies.
It is directed by scientists of Turkish origin, Dr. Özlem Türeci and Prof. Dr. German company made by Uğur Şahin BioNTech and the American pharmaceutical company PfizerThe vaccine was one of the first vaccine names to come up. This vaccine and another American pharmaceutical company Modern vaccine was also developed using RNA (mRNA) technology. These vaccines are different from traditional vaccine methods that inject a weakened and inactive version of the virus into the human body. With RNA (mRNA) technology, it enables the body to produce its own virus protein copies and thus create protective antibodies.
Oxford University and Anglo-Swedish firm AstraZeneca Another vaccine produced in partnership with the coronavirus is produced by putting genes from the pointed proteins of the Coronavirus into another harmless virus. The vaccine produced from the weakened form of the common cold virus transmitted by chimpanzees prevents the virus from infecting the human body. Developed by Sinovac Biotech company in China CoronaVac The vaccine also aims to inject a weakened version of the virus into the body and to gain immunity.
While the Pfizer-BioNTech vaccine can be administered to people aged 16 and over, the Moderna vaccine is suitable for people aged 18 and over. Pfizer-BioNTech vaccine in two doses with an interval of 21 days and CoronaVac 14 days; Moderna is administered in two doses, 4 weeks apart. Again, the Oxford-AstraZeneca vaccine should be administered in two doses.
It is known that the Pfizer-BioNTech vaccine has shown 90-95 percent effectiveness in trials so far. In the Moderna vaccine, this rate is 94.5 percent and it is stated that the effect of the vaccine is less in people aged 65 and over. The Oxford-rate effects of AstraZeneca vaccine while 90 percent of Turkey made coronavac vaccine is effective 90 percent of the volunteers had been announced by the Ministry of Health. It was stated that this rate was between 50-90 percent in Brazil. At this point, it should be emphasized that the effects of vaccines on different races may change.
One of the biggest concerns about vaccines is how to keep them. In this respect, the Pfizer-BioNTech vaccine, which is predicted to cause major logistical difficulties, should be stored at minus 70 degrees. On the other hand, the Moderna vaccine can be stored for up to 6 months at minus 20 degrees. Storage conditions of CoronaVac vaccine and Oxford-AstraZeneca vaccine, which can be stored for up to 6 years without deterioration at 2-8 degrees, are simpler compared to the other two vaccines. Therefore, their distribution is expected to be easier.
Compiled and translated by: Dilara Preserve
References: STAT. A side-by-side comparison of the Pfizer / BioNTech and Moderna vaccines. Taken from: https://www.statnews.com/2020/12/19/a-side-by-side-comparison-of-the-pfizer-biontech-and-moderna-vaccines/
NYTimes. How the Oxford-AstraZeneca Vaccine Works. Retrieved from: https://www.nytimes.com/interactive/2020/health/oxford-astrazeneca-covid-19-vaccine.html?auth=linked-google
BBC. Covid vaccine update: When will others be ready?. Şuradan alınmıştır: https://www.bbc.com/news/health-51665497
CNA. Pfizer-BioNTech, Moderna and Sinovac: A look at three key COVID-19 vaccines. Şuradan alınmıştır: https://www.channelnewsasia.com/news/world/covid-19-vaccines-comparison-pfizer-sinovac-moderna-13784890
Precision Vaccinations. CoronaVac SARS-CoV-2 Vaccine. Taken from: https://www.precisionvaccinations.com/vaccines/coronavac-sars-cov-2-vaccine